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pentobarbital will minimize the level or influence of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.pentobarbital will lower the level or influence of tofacitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Lack of, or reduced reaction to tofacitinib may well arise when coad